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Diffuse Lewy Body Disease:Clinical Features in 15 Cases JNNP 52:709-717, Byrne,E.J., 1989 See this aricle in Pubmed Article Abstract Fifteen cases of diffuse Lewy body disease were diagnosed on pathological grounds during a single year in one health district.The range and frequency of clinical features contrast strikingly with previous reports. The majority of cases presented with classical levodopa-responsive Parkinson's disease either alone(6 cases)or with mild cognitive impairment (3 cases);the remaining 6 cases presented with cognitive impairment alone. In time almost all patients developed both dementia and Parkinsonism.The dementia was cortical in type,but unusual in that most(12 cases)showed day-to-day fluctuation in severity at some point in their illness.These findings suggest that diffuse Lewy body disease is not rare,and that it presents in a range of ways from dementia with subsequent Parkinsonism to Parkinson's disease with subsequent dementia.The latter mode of presentation suggests that it should be considered as a significant pathological substrate of dementia in Parkinson's disease.

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(click to filter results - removes previous filter) burst suppression pattern,electroencephalogram delusion dementia falling hallucination L-dopa Lewy body disease,diffuse neuropathology Parkinson disease Parkinson disease,L-dopa nonresponsive Parkinsonism syndrome

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